DEGRONOPEDIA

What's new

degron conservation scores
searching by custom degron motifs
defining custom proteolytic sites by specifying a sequence motif with the indicated cleavage pattern
handling of experimental structures
prediction of disorder regions using IUPred3 software
possibility to pass UniProt ID when querying by structure
Degron motifs subpage with possibility to download the list of degron motifs
queue management system

Update

list of degron motifs
post-translational modification sites (due to the PhosphoSitePlus update to version 6.7.0.1)
mutation sites (due to the COSMIC update to version 97)
E3 ubiquitin ligase interactomes (due to the new IntAct release no 243)
AlphaFold2 structures of proteomes (due to the AlphaFold Protein Structure Database update to version 4)
Tutorial subpage

What's new

What's new

screening for degron motifs in the query
calculation of the Gravy hydrophobicity index of N-/C-terminus of the query
structural context (solvent-accessibility, location in the disordered region, secondary structure) for each degron motif found
information on post-translational modifications and mutations occurring within each degron motif and its flanking regions
degron context according to the tripartite model proposed by Guharoy et al., 2016
experimental or machine learning-predicted Protein Stability Index (PSI) of the N-/C-terminus of the query
information on E3 ubiquitin ligases interacting with the query
simulations of proteolytic cleavage, followed by a search for degron motifs in each newly emerged N-/C-terminus
visualization of the location of degron motifs in the sequence overlaid with structural data, post-translational modifications and mutations